Editorial by Rodolfo Montironi, Who classification of tumours of the breast fourth edition pdf Cheng, Marina Scarpelli and Antonio Lopez-Beltran on pp. During this time, significant new knowledge has been generated about the pathology and genetics of these tumours.
Intraductal carcinoma of the prostate is a newly recognized entity in the 2016 WHO classification. In most cases, it represents intraductal spread of aggressive prostatic carcinoma and should be separated from high-grade prostatic intraepithelial neoplasia. New acinar adenocarcinoma variants are microcystic adenocarcinoma and pleomorphic giant cell adenocarcinoma. Modifications to the Gleason grading system are incorporated into the 2016 WHO section on grading of prostate cancer, and it is recommended that the percentage of pattern 4 should be reported for Gleason score 7. The new WHO classification further recommends the recently developed prostate cancer grade grouping with five grade groups. For bladder cancer, the 2016 WHO classification continues to recommend the 1997 International Society of Urological Pathology grading classification. Newly described or better defined noninvasive urothelial lesions include urothelial dysplasia and urothelial proliferation of uncertain malignant potential, which is frequently identified in patients with a prior history of urothelial carcinoma.
Pathologists should mention the percentage of divergent histologies in the pathology report. Intraductal carcinoma of the prostate is a newly recognized entity in the 2016 World Health Organization classification. Better defined noninvasive urothelial lesions include urothelial dysplasia and urothelial proliferation of uncertain malignant potential. Check if you have access through your login credentials or your institution. 2016 European Association of Urology. Editorial by Rodolfo Montironi, Liang Cheng, Marina Scarpelli and Antonio Lopez-Beltran on pp.