Since then one stages of huntington’s disease pdf the most important advances in HD research has been the generation of various mouse models that enable the exploration of early pathological, molecular and cellular abnormalities produced by the mutation. In addition, these models have made it possible to test different pharmacological approaches to delay the onset or slow the progression of HD.
In this article, insights gained from mouse models towards the understanding of HD and the design of new therapeutic strategies are discussed. Check if you have access through your login credentials or your institution. Cognitive assessment in HD research is an exciting and evolving field. After four decades of cognitive research in HD, important lessons have been learnt. We review the important historical developments in the study of cognition in HD.
Important considerations when including cognitive assessment in HD research are discussed. Finally, we outline future directions for cognitive research in HD. HD have become much more sophisticated. In this review, we provide a summary of the advances in cognitive research in HD to date, and outline the key considerations for researchers planning to include cognitive assessment in their studies of HD. HD, practice effects, and specific issues for multi-site research.